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Journal Article

CNTNAP2 and language processing in healthy individuals as measured with ERPs


Hagoort,  Peter
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands;
Radboud University Nijmegen, Behavioural Science Institute, Nijmegen, The Netherlands;
Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society;

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Kos, M., Van den Brink, D., Snijders, T. M., Rijpkema, M., Franke, B., Fernandez, G., et al. (2012). CNTNAP2 and language processing in healthy individuals as measured with ERPs. PLoS One, 7(10), e46995. doi:10.1371/journal.pone.0046995.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-1C64-4
The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.