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Logan graphical analysis for quantitative evaluation of calcium channel activity in the pituitary gland using manganese-enhanced MRI (MEMRI)

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Leuze,  Christoph
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
National Institute of Radiological Sciences, Chiba, Japan;

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Leuze, C., Aoki, I., & Kimura, Y. (2010). Logan graphical analysis for quantitative evaluation of calcium channel activity in the pituitary gland using manganese-enhanced MRI (MEMRI). Talk presented at 18th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Stockholm, Sweden. 2010-05-01 - 2010-05-07.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-211F-C
Abstract
Logan graphical analysis (LGA), common in PET for the quantitative analysis of neuroreceptors, was performed with MRI to investigate the influence of stimulants and inhibitors on the Calcium channel activity in animal brain tissue. In this study LGA is applied to data which was acquired by measuring the concentrations of Manganese (Mn) in tissue and blood over a certain period of time after Mn-injection. The Mn uptake between experiments was varied by the excitatory neurotransmitter Glutamate and the Calcium channel blocker Verapamil. The analysis successfully delivers information about the varying in- and outflow of Mn from blood to tissue.