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Changes to the fractional anisotropy & mean diffusivity of in vivo rat brain measured at short effective diffusion-times

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Leuze,  Christoph
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Kershaw, J., Leuze, C., Obata, T., Kanno, I., & Aoki, I. (2011). Changes to the fractional anisotropy & mean diffusivity of in vivo rat brain measured at short effective diffusion-times. Talk presented at 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Montreal, QC, Canada. 2011-05-07 - 2011-05-13.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-2121-4
Abstract
A sequence with oscillating motion-probing gradients was applied to investigate the restricted or hindered motion of water in in vivo rat brain tissue by observing changes to the apparent diffusion tensor, fractional anisotropy (FA) and mean diffusivity (MD) as the effective diffusion-time is decreased. Imaging was performed in a sagittal slice through the rat cerebellum and corpus callosum, which contain most of the white matter in the rat brain. Paired-t tests found significant differences in the FA of the corpus callosum and cerebellar white matter after the effective diffusion-time was decreased from 7.5 ms to 3.75 ms. Significant differences were also found for the MD in both grey and white matter. It is anticipated that normal and pathological in vivo tissue structure can be probed with this technique.