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Cerebellar transcranial direct current stimulation modulates verbal working memory

MPS-Authors
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Böhringer,  Andreas
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Central Institute of Mental Health, Mannheim, Germany;

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Macher,  Katja
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Dukart,  Jürgen
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Pleger,  Burkhard
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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brainstim_2012.pdf
(Publisher version), 236KB

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Citation

Böhringer, A., Macher, K., Dukart, J., Villringer, A., & Pleger, B. (2013). Cerebellar transcranial direct current stimulation modulates verbal working memory. Brain Stimulation, 6(4), 649-653. doi:10.1016/j.brs.2012.10.001.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-233C-B
Abstract
Background Neuroimaging studies show cerebellar activations in a wide range of cognitive tasks and patients with cerebellar lesions often present cognitive deficits suggesting a cerebellar role in higher-order cognition. Objective We used cathodal transcranial direct current stimulation (tDCS), known to inhibit neuronal excitability, over the cerebellum to investigate if cathodal tDCS impairs verbal working memory, an important higher-order cognitive faculty. Method We tested verbal working memory as measured by forward and backward digit spans in 40 healthy young participants before and after applying cathodal tDCS (2 mA, stimulation duration 25 min) to the right cerebellum using a randomized, sham-controlled, double-blind, cross-over design. In addition, we tested the effect of cerebellar tDCS on word reading, finger tapping and a visually cued sensorimotor task. Results In line with lower digit spans in patients with cerebellar lesions, cerebellar tDCS reduced forward digit spans and blocked the practice dependent increase in backward digit spans. No effects of tDCS on word reading, finger tapping or the visually cued sensorimotor task were found. Conclusion Our results support the view that the cerebellum contributes to verbal working memory as measured by forward and backward digit spans. Moreover, the induction of reversible “virtual cerebellar lesions” in healthy individuals by means of tDCS may improve our understanding of the mechanistic basis of verbal working memory deficits in patients with cerebellar lesions.