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Automated characterization of gene expression patterns with an atlas of the mouse brain.

MPG-Autoren
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Eichele,  G.
Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society;

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Zitation

Carson, J. P., Ju, T., Thaller, C., Warren, J., Bello, M., Kakadiaris, I., et al. (2004). Automated characterization of gene expression patterns with an atlas of the mouse brain. IEEE Engineering in Medicine and Biology, 4, 2917-2920.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-2397-C
Zusammenfassung
A spatio-temporal map of gene activity in the brain would be an important contribution to the understanding of brain development, disease, and function. Such a resource is now possible using high-throughput in situ hybridization, a method for transcriptome-wide acquisition of cellular resolution gene expression patterns in serial tissue sections. However, querying an enormous quantity of image data requires computational methods for describing and organizing gene expression patterns in a consistent manner. In addressing this, we have developed procedures for automated annotation of gene expression patterns in the postnatal mouse brain.