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Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide

MPS-Authors
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Willwacher,  Jens
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Kausch-Busies,  Nina
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Willwacher, J., Kausch-Busies, N., & Fürstner, A. (2012). Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide. Angewandte Chemie International Edition, 51(48), 12041-12046. doi:10.1002/anie.201206670.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-2562-1
Abstract
Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.