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Journal Article

A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.

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Citation

Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997). A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell, 91(7), 1055-1064. doi:10.1016/S0092-8674(00)80495-X.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-4A70-6
Abstract
A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.