RIGUI, a putative mammalian ortholog of the Drosophila period gene.

Sun, Z. S.; Albrecht, U.; Zhuchenko, O.; Bailey, J.; Eichele, G.; Lee, C. C.

doi:10.1016/S0092-8674(00)80366-9

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RIGUI, a putative mammalian ortholog of the Drosophila period gene.

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Eichele, G.
Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society;

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Citation

Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., & Lee, C. C. (1997). RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell, 90(6), 1003-1011. doi:10.1016/S0092-8674(00)80366-9.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-4A79-3

Abstract

The molecular components of mammalian circadian clocks are elusive. We have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period. The highly conserved mouse homolog (m-rigui) is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN), the master regulator of circadian clocks in mammals. Circadian expression in the SCN continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of m-rigui expression in the SCN. m-rigui transcripts also appear in a periodic pattern in Purkinje neurons, pars tuberalis, and retina, but with a timing of oscillation different from that seen in the SCN. Sequence homology and circadian patterns of expression suggest that RIGUI is a mammalian ortholog of the Drosophila period gene, raising the possibility that a regulator of circadian clocks is conserved.