The integrin-actin connection, an eternal love affair

Brakebusch, C.; Fässler, R.

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

The integrin-actin connection, an eternal love affair

MPS-Authors

/persons/resource/persons77799

Brakebusch, C.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons77945

Fässler, R.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Brakebusch, C., & Fässler, R. (2003). The integrin-actin connection, an eternal love affair. EMBO Journal, 22(10), 2324-2333.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-6BEB-7

Abstract

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.