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Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death

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Meister,  G.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Bandilla,  M.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Fischer,  U.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Jablonka, S., Holtmann, B., Meister, G., Bandilla, M., Rossoll, W., Fischer, U., et al. (2002). Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 10126-10131.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6EB2-D
Abstract
Neuronal degeneration in spinal muscular atrophy is caused by reduced expression of the survival motor neuron (SMN) protein. SMN and the tightly interacting Gemin2 form part of a macromolecular complex (SMN complex) that mediates assembly of spliceo-somal small nuclear ribonucleoproteins (U snRNPs). We used mouse genetics to investigate the function of this complex in motoneuron maintenance. Reduced Smn/Gemin2 protein levels lead to disturbed U snRNP assembly as indicated by reduced nuclear accumulation of Sm proteins. This finding correlates with enhanced motoneuron degeneration in Gemin2(+/-) / Smn(+/-) mice. Our data provide in vivo evidence that impaired production of U snRNPs contributes to motoneuron degeneration.