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Electron tomography of molecules and cells

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Baumeister, W., Grimm, R., & Walz, J. (1999). Electron tomography of molecules and cells. Trends in Cell Biology, 9(2), 81-85.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-71AF-B
Abstract
Electron tomography is the most winery applicable method for obtaining three-dimensional information by electron microscopy. It is, in fact, the only method suitable for investigating pleomorphic structures, such as many supramolecular assemblies, organelles and cells. With the recent development of automated low-dose data-acquisition schemes, it is now possible to study molecules and cells embedded in vitreous ice. This opens up new horizons for investigating the functional organization of cellular components with minimal perturbation of the cellular context. [References: 42]