English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death

MPS-Authors
There are no MPG-Authors available
Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Pitzer, F., Dantes, A., Fuchs, T., Baumeister, W., & Amsterdam, A. (1996). Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death. FEBS Letters, 394(1), 47-50.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-72D4-D
Abstract
Apoptosis can be initiated in immortalized cAMP-stimulated rat ovarian granulosa cells by induction of wild-type p53 activity, Immunocytochemical studies using confocal microscopy reveal that in apoptotic, unlike in normal growing cells, the proteasomes are removed from the nucleus and accumulate within the apoptotic blebs at the periphery of the cell. In parallel, a striking reorganization of the actin cytoskeleton is observed which forms a spherical network separating the apoptotic blebs from the cytoplasmic organelles, such as mitochondria and lipid droplets which remain in the perinuclear region, The reorganization of the actin cytoskeleton as well as disappearance of proteasomes from the nucleus suggest possible function of proteasomes in apoptotic regulation. [References: 26]