Structure of a molecular chaperone from a thermophilic archaebacterium

Phipps, B. M.; Typke, D.; Hegerl, R.; Volker, S.; Hoffmann, A.; Stetter, K. O.; Baumeister, W.

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Structure of a molecular chaperone from a thermophilic archaebacterium

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Phipps, B. M., Typke, D., Hegerl, R., Volker, S., Hoffmann, A., Stetter, K. O., et al. (1993). Structure of a molecular chaperone from a thermophilic archaebacterium. Nature, 361(6411), 475-477.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-73CF-4

Abstract

Reports the three-dimensional structure of the thermosome from Pyrodictium occultum by random conical tilt reconstruction from electron micrographs. The reconstruction reveals a complex consisting of two rings of eight subunits each, stacked face-to-face. The subunits are kidney-shaped and composed of at least two domains. In the centre of the thermosome is a large cavity of about 6.7 nm diameter; the opening of this cavity on each face of the complex is partially blocked by a mass which appears to be weakly connected to the eight-membered ring. (29 References).