Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S 
subunit

Muhs, M.; Yamamoto, H.; Ismer, J.; Takaku, H.; Nashimoto, M.; Uchiumi, T.; Nakashima, N.; Mielke, T.; Hildebrand, P. W.; Nierhaus, K. H.; Spahn, C. M.

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Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit

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Yamamoto, H.
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Mielke, T.
Imaging/Electron Microscopy (Head: Rudi Lurz/Thorsten Mielke), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Nierhaus, K. H.
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

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Spahn, C. M.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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引用

Muhs, M., Yamamoto, H., Ismer, J., Takaku, H., Nashimoto, M., Uchiumi, T., Nakashima, N., Mielke, T., Hildebrand, P. W., Nierhaus, K. H., & Spahn, C. M. (2011). Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Research, 39(12), 5264-75. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21378123 http://nar.oxfordjournals.org/content/39/12/5264.full.pdf.

引用: https://hdl.handle.net/11858/00-001M-0000-0010-78EA-2

要旨

Some viruses exploit internal initiation for their propagation in the host cell. This type of initiation is facilitated by structured elements (internal ribosome entry site, IRES) upstream of the initiator AUG and requires only a reduced number of canonical initiation factors. An important example are IRES of the virus family Dicistroviridae that bind to the inter-subunit side of the small ribosomal 40S subunit and lead to the formation of elongation-competent 80S ribosomes without the help of any initiation factor. Here, we present a comprehensive functional and structural analysis of eukaryotic-specific ribosomal protein rpS25 in the context of this type of initiation and propose a structural model explaining the essential involvement of rpS25 for hijacking the ribosome.