English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit

MPS-Authors
/persons/resource/persons50654

Yamamoto,  H.
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50431

Mielke,  T.
Imaging/Electron Microscopy (Head: Rudi Lurz/Thorsten Mielke), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50444

Nierhaus,  K. H.
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50563

Spahn,  C. M.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Muhs, M., Yamamoto, H., Ismer, J., Takaku, H., Nashimoto, M., Uchiumi, T., et al. (2011). Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Research, 39(12), 5264-75. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21378123 http://nar.oxfordjournals.org/content/39/12/5264.full.pdf.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-78EA-2
Abstract
Some viruses exploit internal initiation for their propagation in the host cell. This type of initiation is facilitated by structured elements (internal ribosome entry site, IRES) upstream of the initiator AUG and requires only a reduced number of canonical initiation factors. An important example are IRES of the virus family Dicistroviridae that bind to the inter-subunit side of the small ribosomal 40S subunit and lead to the formation of elongation-competent 80S ribosomes without the help of any initiation factor. Here, we present a comprehensive functional and structural analysis of eukaryotic-specific ribosomal protein rpS25 in the context of this type of initiation and propose a structural model explaining the essential involvement of rpS25 for hijacking the ribosome.