The caspase recruitment domain-containing protein 8 (CARD8) negatively 
regulates NOD2-mediated signaling.

von Kampen, O.; Lipinski, S.; Till, A.; Martin, S. J.; Nietfeld, W.; Lehrach, H.; Schreiber, S.; Rosenstiel, P.

doi:10.1074/jbc.M110.127480

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The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

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Nietfeld, W.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Lehrach, H.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

von Kampen, O., Lipinski, S., Till, A., Martin, S. J., Nietfeld, W., Lehrach, H., et al. (2010). The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling. He Journal of Biological Chemistry, 285(26), 19921-19926. doi:10.1074/jbc.M110.127480.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-7B5A-0

Abstract

Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.