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Journal Article

Regulatory crosstalk of the metabolic network

MPS-Authors

Gruning,  N. M.
Max Planck Society;

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Lehrach,  H.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Ralser,  M.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Gruning, N. M., Lehrach, H., & Ralser, M. (2010). Regulatory crosstalk of the metabolic network. Trends in Biochemical Sciences, 35(4), 220-227. doi:10.1016/j.tibs.2009.12.001.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7C22-4
Abstract
The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli and environmental conditions. Through monitoring by metabolite responsive macromolecules, metabolic pathways interact with the transcriptome and proteome. Whereas pathway interconnecting cofactors and substrates report on the overall state of the network, specialised intermediates measure the activity of individual functional units. Transitions in the network affect many of these regulatory metabolites, facilitating the parallel regulation of the timing and control of diverse biological processes. The metabolic network controls its own balance, chromatin structure and the biosynthesis of molecular cofactors; moreover, metabolic shifts are crucial in the response to oxidative stress and play a regulatory role in cancer.