Regulation of muscle development by DPF3, a novel histone acetylation and 
methylation reader of the BAF chromatin remodeling complex

Lange, Martin; Kaynak, Bogac; Forster, Ulrike B.; Tönjes, Martje; Fischer, Jenny J.; Grimm, Christina; Schlesinger, Jenny; Just, Steffen; Dunkel, Ilona; Krueger, Tammo; Mebus, Siegrun; Lehrach, Hans; Lurz, Rudi; Gobom, Johan; Rottbauer, Wolfgang; Abdelilah-Seyfried, Salim; Sperling, Silke

doi:10.1101/gad.471408

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Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex

MPS-Authors

Lange, Martin
Max Planck Society;

Kaynak, Bogac
Max Planck Society;

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Tönjes, Martje
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Fischer, Jenny J.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Grimm, Christina
In vitro Ligand Screening (Zoltán Konthur), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Schlesinger, Jenny
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Dunkel, Ilona
Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

Krueger, Tammo
Max Planck Society;

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Lehrach, Hans
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Lurz, Rudi
Max Planck Society;

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Gobom, Johan
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50492

Sperling, Silke
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Lange, M., Kaynak, B., Forster, U. B., Tönjes, M., Fischer, J. J., Grimm, C., et al. (2008). Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes and Development, 22(17), 2370-2384. doi:10.1101/gad.471408.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-7F1E-1

Abstract

Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone–DNA interactions. We present DPF3, a new epigenetic key factor for heart and muscle development characterized by a double PHD finger. DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4. Thus, DPF3 may represent the first plant homeodomains that bind acetylated lysines, a feature previously only shown for the bromodomain. During development Dpf3 is expressed in the heart and somites of mouse, chicken, and zebrafish. Morpholino knockdown of dpf3 in zebrafish leads to incomplete cardiac looping and severely reduced ventricular contractility, with disassembled muscular fibers caused by transcriptional deregulation of structural and regulatory proteins. Promoter analysis identified Dpf3 as a novel downstream target of Mef2a. Taken together, DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling. Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones.