Reductive stress on life span extension in C. elegans

Ralser, Markus; Benjamin, Ivor J.

doi:10.1186/1756-0500-1-19

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Reductive stress on life span extension in C. elegans

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Ralser, Markus
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Ralser, M., & Benjamin, I. J. (2008). Reductive stress on life span extension in C. elegans. BMC Research Notes, 1, 1:19-1:19. doi:10.1186/1756-0500-1-19.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-7FB7-9

Abstract

Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280–293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants.