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Journal Article

Factors directing telomere dynamics in synaptic meiosis


Scherthan,  Harry
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Scherthan, H. (2006). Factors directing telomere dynamics in synaptic meiosis. Biochemical Society Transactions, 34(4), 550-553. doi:10.1042/BST0340550.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8464-D
Meiosis creates haploid cells from diploid progenitors. Homologous chromosomes are moved, paired and segregated from each other in a specialized meiosis I division. A second division that lacks a preceding S-phase produces haploid cells. In prophase I, chromosomes attach with their telomeres to the nuclear envelope and undergo oscillating movements that become restricted to a limited nuclear sector during the widely conserved bouquet stage. Recent observations in budding yeast meiosis suggest that telomere clustering depends on actin, whereas exit from the bouquet stage requires meiotic cohesin. Telomere clustering may also be modulated by progression in recombination. These observations suggest that the unique meiotic nuclear topology and telomere dynamics are regulated at different levels.