User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse




Conference Paper

Finding disease specific alterations in the co-expression of genes


Kostka,  Dennis
Max Planck Society;


Spang,  Rainer
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Kostka, D., & Spang, R. (2004). Finding disease specific alterations in the co-expression of genes. Biioinformatics, 20, Suppl. 1, i194-i199.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-87FB-3
Motivation: Standard analysis routines for microarray data aim at differentially expressed genes. In this paper, we address the complementary problem of detecting sets of differentially co-expressed genes in two phenotypically distinct sets of expression profiles. Results: We introduce a score for differential co-expression and suggest a computationally efficient algorithm for finding high scoring sets of genes. The use of our novel method is demonstrated in the context of simulations and on real expression data from a clinical study.