Finding disease specific alterations in the co-expression of genes

Kostka, Dennis; Spang, Rainer

doi:10.1093/bioinformatics/bth909

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Finding disease specific alterations in the co-expression of genes

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Kostka, Dennis
Max Planck Society;

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Spang, Rainer
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Kostka, D., & Spang, R. (2004). Finding disease specific alterations in the co-expression of genes. Biioinformatics, 20, Suppl. 1, i194-i199.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-87FB-3

Abstract

Motivation: Standard analysis routines for microarray data aim at differentially expressed genes. In this paper, we address the complementary problem of detecting sets of differentially co-expressed genes in two phenotypically distinct sets of expression profiles. Results: We introduce a score for differential co-expression and suggest a computationally efficient algorithm for finding high scoring sets of genes. The use of our novel method is demonstrated in the context of simulations and on real expression data from a clinical study.