Tipping the balance toward longevity

Antebi, Adam

doi:10.1016/S1534-5807(04)00068-1

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Tipping the balance toward longevity

MPS-Authors

/persons/resource/persons50070

Antebi, Adam
Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Antebi, A. (2004). Tipping the balance toward longevity. Developmental Cell, 6(3), 315-316. doi:10.1016/S1534-5807(04)00068-1.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8899-8

Abstract

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.