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Journal Article

Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase

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Adelfalk,  Caroline
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Adelfalk, C., Kontou, M., Hirsch-Kauffmann, M., & Schweiger, M. (2003). Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase. FEBS Letters, 554(1-2), 55-58. doi:10.1016/S0014-5793(03)01088-3.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-896C-6
Abstract
Werner’s syndrome is a rare disease of premature ageing. The WRN gene product defective in this disorder belongs to the RecQ helicase family and is thought to be involved in DNA metabolism. Another protein, which plays an important role in both DNA replication and repair, is the poly-ADP ribosyl transferase. Here we demonstrate an interaction of these two proteins resulting in ADP-ribosylation of the WRN protein. These results imply that WRN is involved in DNA replication and in DNA repair.