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SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae?

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Marchfelder,  Uta
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Rateitschak,  Katja
Max Planck Society;

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Ehrenhofer-Murray,  Ann E.
Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Marchfelder, U., Rateitschak, K., & Ehrenhofer-Murray, A. E. (2003). SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae? Yeast, 20(9), 797-801. doi:10.1002/yea.1001.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-89F1-9
Abstract
The proteins Sir2, Sir3 and Sir4 repress transcription of the silent mating-type loci HML and HMR and of reporter genes inserted at telomeres. Previous microarray analyses suggested that additional non-telomeric genes exist which are repressed by the Sir proteins. In this study, we tested the expression of 12 such genes by Northern analysis and RT-PCR. However, we were unable to verify their SIR-dependent regulation, which suggests that SIR-mediated repression may be restricted to the known repressed regions.