High rate of constitutional chromosomal rearrangements in apparently sporadic 
ALS

Meyer, T.; Alber, B.; Roemer, K.; Martin, T.; Kalscheuer, V. M.; Gottert, E.; Zang, K. D.; Ludolph, A. C.; Ropers, H. H.; Prudlo, J.

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High rate of constitutional chromosomal rearrangements in apparently sporadic ALS

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Kalscheuer, V. M.
Chromosome Rearrangements and Disease (Vera Kalscheuer), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Ropers, H. H.
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Meyer, T., Alber, B., Roemer, K., Martin, T., Kalscheuer, V. M., Gottert, E., et al. (2003). High rate of constitutional chromosomal rearrangements in apparently sporadic ALS. Neurology, 60(8), 1348-1350.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8A66-A

Abstract

Of 85 patients with ALS, the authors identified 3 patients with balanced translocations and 2 patients with pericentric inversions, all affecting distinct chromosomal loci. The high rate of constitutional aberrations (5.9%) suggests that ALS is, in part, associated with recombination-based rearrangements of genomic sequences.