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Journal Article

Tying rings for sex


Lurz,  Rudi
Max Planck Society;

Lanka,  Erich
Max Planck Society;

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Kalkum, M., Eisenbrandt, R., Lurz, R., & Lanka, E. (2002). Tying rings for sex. 8, 382-387.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8BD2-0
The primary component of the sex pilus encoded by IncP (RP4) and Ti plasmids has been identified as a circular pilin protein with a peptide bond between the amino and carboxyl terminus. Here, we review the key experiments that led to this discovery, and the present mechanistic model for pilin-precursor processing and the cyclization reaction. In addition, we discuss the implications for horizontal gene transfer in bacterial conjugation. Abstract 2: The primary component of the pilus encoded by IncP and Ti plasmids has been identified as a cyclic protein whose amino and carboxyl termini are joined by covalent head-to-tail peptide bonds. Here, a possible cyclization mechanism and the rold of cyclic peptides in horizontal gene transfer are discussed.