Headache in patients with pituitary adenoma: Clinical and paraclinical findings

Schankin, Christoph J.; Reifferscheid, Anna K.; Krumbholz, Markus; Linn, Jennifer; Rachinger, Walter; Langer, Sigrid; Sostak, Petra; Arzberger, Thomas; Kretzschmar, Hans; Straube, Andreas

doi:10.1177/0333102412462639

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Headache in patients with pituitary adenoma: Clinical and paraclinical findings

MPS-Authors

/persons/resource/persons38948

Krumbholz, Markus
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Schankin, C. J., Reifferscheid, A. K., Krumbholz, M., Linn, J., Rachinger, W., Langer, S., et al. (2012). Headache in patients with pituitary adenoma: Clinical and paraclinical findings. Cephalalgia, 32(16), 1198-1207. doi:10.1177/0333102412462639.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-7671-A

Abstract

Aim: The aim of this article is to generate hypotheses for the mechanism of pituitary adenoma headache.
Patients and methods: Fifty-eight patients with pituitary adenoma were prospectively analysed for prevalence and manifestation of tumour headache. Intrapersonal and neoplasm-associated risk factors were assessed.
Results: Twenty-four patients (41%) had tumour-attributed headache, seven had migraine-like, 11 tension-type headache-like headache, and three both. Cluster headache-like headache was found once, and two headaches remained unclassified. Tumour-attributed headache was associated with a positive history of headache (p = 0.03; OR 3.4), nicotine abuse (p<0.01; OR 4.7), intake of acute headache medication (p = 0.04; OR 3.3), and a higher tumour proliferation indicated by a Ki67-labelling index (LI) >3% (p = 0.02; OR 11.0). For patients with migraine-like tumour-attributed headache, risk factors were younger age (p = 0.02), nicotine abuse (p<0.01; OR 10.9), acute headache treatment (p<0.01; OR 9.0), and Ki67-LI >3% (p = 0.03; OR 14.1). For tension-type headache-like headache, the main risk factor was a positive history of tension-type headache (p = 0.045; OR 5.6).
Conclusion: Headache predisposition and local tumour effects might be important for the pathophysiology of pituitary adenoma headache and tumour headache in general.