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Journal Article

Age-specific effects of early MK-801 treatment on working memory in female rats


Wang,  X. D.
AG Schmidt, Mathias, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Su, Y. A., Wang, X. D., Li, J. T., Guo, C. M., Feng, Y., Yang, Y., et al. (2011). Age-specific effects of early MK-801 treatment on working memory in female rats. NeuroReport, 22(8), 402-406.

Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-8E82-E
The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats. NeuroReport 22:402-406 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.