Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

Reul, JMHM; Holsboer, F

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

MPS-Authors

Reul, JMHM
Max Planck Institute of Psychiatry, Max Planck Society;

Holsboer, F
Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Reul, J., & Holsboer, F. (2002). Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Current Opinion in Pharmacology, 2(1), 23-33.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-A24F-A

Abstract

Corticotropin-releasing factor (CRF) and its related family members are implicated in stress-related disorders such as anxiety and depression. Recently, two new members of this neuropeptide family have been discovered in the brain: urocortin 11 (also known as stresscopin-related peptide) and urocortin III (also known as stresscopin). These urocortins are selective agonists for the CRF2 receptor, show a distinct neuroanatomical localization and are involved in stress-coping responses such as anxiolysis. Thus, CRF the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress respons