mPet-1, a mouse ETS-domain transcription factor, is expressed in central 
serotonergic neurons

Pfaar, H; von Holst, A; Weisenhorn, DMV; Brodski, C; Guimera, J; Wurst, W

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons

MPS-Authors

Pfaar, H
Max Planck Institute of Psychiatry, Max Planck Society;

von Holst, A
Max Planck Institute of Psychiatry, Max Planck Society;

Weisenhorn, DMV
Max Planck Institute of Psychiatry, Max Planck Society;

Brodski, C
Max Planck Institute of Psychiatry, Max Planck Society;

Guimera, J
Max Planck Institute of Psychiatry, Max Planck Society;

Wurst, W
Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Pfaar, H., von Holst, A., Weisenhorn, D., Brodski, C., Guimera, J., & Wurst, W. (2002). mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Development Genes and Evolution, 212(1), 43-46.

引用: https://hdl.handle.net/11858/00-001M-0000-000E-A255-9

要旨

Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet-1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co- localizes precisely with the serotonin transporter (Sert), which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Ser