Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi 
network

von Blume, Julia; Alleaume, Anne-Marie; Kienzle, Christine; Carreras-Sureda, Amado; Valverde, Miguel; Malhotra, Vivek

doi:10.1083/jcb.201207180

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network

MPS-Authors

/persons/resource/persons77771

von Blume, Julia
von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons81012

Kienzle, Christine
von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

von Blume, J., Alleaume, A.-M., Kienzle, C., Carreras-Sureda, A., Valverde, M., & Malhotra, V. (2012). Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network. JOURNAL OF CELL BIOLOGY, 199(7), 1057-1066. doi:10.1083/jcb.201207180.

引用: https://hdl.handle.net/11858/00-001M-0000-000E-AC28-A

要旨

Ca2+ import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca2+ retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca2+ import into the TGN; it binds secretory cargo in a Ca2+-dependent reaction and is required for its sorting at the TGN.