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Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

MPS-Authors
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Seiler,  Katharina
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

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Tsuneto,  Motokazu
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

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Melchers,  Fritz
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

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Fulltext (public)

J_Biomed_Biotechnol_2011_895086.pdf
(Publisher version), 524KB

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Citation

Seiler, K., Tsuneto, M., & Melchers, F. (2011). Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation. Journal of Biomedicine and Biotechnology, 895086. doi:10.1155/2011/895086.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-BF3C-B
Abstract
We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.