English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging

MPS-Authors
/persons/resource/persons19827

Lv,  Yating
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Mind and Brain Institute and Berlin School of Mind and Brain, Charité and Humboldt University, Berlin, Germany;

/persons/resource/persons19840

Margulies,  Daniel S.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Mind and Brain Institute and Berlin School of Mind and Brain, Charité and Humboldt University, Berlin, Germany;

/persons/resource/persons19822

Long,  Xiangyu
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Mind and Brain Institute and Berlin School of Mind and Brain, Charité and Humboldt University, Berlin, Germany;
Center for Stroke Research, Charité–Universitätsmedizin, Berlin, Germany;
Department of Neurology, Charité–Universitätsmedizin, Berlin, Germany;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Lv, Y., Margulies, D. S., Craddock, R. C., Long, X., Winter, B., Gierhake, D., et al. (2013). Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging. Annals of Neurology, 73(1), 136-140. doi:10.1002/ana.23763.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-E2F4-7
Abstract
Temporal delay in blood oxygenation level–dependent (BOLD) signals may be sensitive to perfusion deficits in acute stroke. Resting-state functional magnetic resonance imaging (rsfMRI) was added to a standard stroke MRI protocol. We calculated the time delay between the BOLD signal at each voxel and the whole-brain signal using time-lagged correlation and compared the results to mean transit time derived using bolus tracking. In all 11 patients, areas exhibiting significant delay in BOLD signal corresponded to areas of hypoperfusion identified by contrast-based perfusion MRI. Time delay analysis of rsfMRI provides information comparable to that of conventional perfusion MRI without the need for contrast agents.