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Connectivity architecture and subdivision of the human inferior parietal cortex revealed by diffusion MRI

MPS-Authors
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Ruschel,  Michael
Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Knösche,  Thomas R.
Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Friederici,  Angela D.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Geyer,  Stefan
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Anwander,  Alfred
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Ruschel, M., Knösche, T. R., Friederici, A. D., Turner, R., Geyer, S., & Anwander, A. (2014). Connectivity architecture and subdivision of the human inferior parietal cortex revealed by diffusion MRI. Cerebral Cortex, 24(9), 2436-2448. doi:10.1093/cercor/bht098.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-EAC2-A
Abstract
The human inferior parietal cortex convexity (IPCC) is an important association area, which integrates auditory, visual and somatosensory information. However, the structural organization of the IPCC is a controversial issue. For example, cytoarchitectonic parcellations reported in the literature range from two to seven areas. Moreover, anatomical descriptions of the human IPCC are often based on experiments in the macaque monkey. In this study we used diffusion-weighted magnetic resonance imaging (dMRI) combined with probabilistic tractography to quantify the connectivity of the human IPCC, and used this information to parcellate this cortex area. This provides a new structural map of the human IPCC, comprising three sub-areas (IPCa, IPCm, IPCp) of comparable size, in a rostro-caudal arrangement in the left and right hemisphere. Each sub-area is characterized by a connectivity fingerprint and the parcellation is similar to the subdivision reported for the macaque IPCC (rostro-caudal areas areas PF, PFG, and PG). However, the present study also reliably demonstrates new structural features in the connectivity pattern of the human IPCC, which are not known to exist in the macaque. This study quantifies inter-subject variability by providing a population representation of the sub-area arrangement, and demonstrates substantial lateralization of the connectivity patterns of IPCC.