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High-resolution MRI and diffusion-weighted imaging of the human habenula at 7 tesla

MPS-Authors
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Strotmann,  Barbara
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Heidemann,  Robin M.
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Siemens Sector Healthcare, Erlangen, Germany;

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Anwander,  Alfred
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiss,  Marcel
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Strotmann, B., Heidemann, R. M., Anwander, A., Weiss, M., Trampel, R., Villringer, A., et al. (2014). High-resolution MRI and diffusion-weighted imaging of the human habenula at 7 tesla. Journal of Magnetic Resonance Imaging, 39(4), 1018-1026. doi:10.1002/jmri.24252.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-F575-1
Abstract
Purpose To investigate the feasibility of discriminating the habenula in human brain using high-resolution structural MRI and diffusion-weighted imaging at 7 Tesla (T). Materials and Methods MRI experiments included a MP2RAGE and GRE sequence to acquire quantitative parameter maps of T1, T2*, and a calculated proton density map and the combined approach of zoomed and parallel imaging (ZOOPPA) to obtain dw images. Probabilistic tractography algorithms were used to identify multiple fiber orientations in submillimetre voxels, and constrained spherical deconvolution to resolve orientations in regions where fibers cross. Results Maps of T1, T2*, and proton density showed high contrast of the human habenula. The lateral habenula and its commissure can be distinguished from medial habenula and adjacent tissue. DWI data with 0.7 mm isotropic resolution revealed that fiber populations differ in medial and lateral habenula and two major fiber bundles that connect habenular nuclei with forebrain structures and brainstem. Conclusion High resolution 7T MR imaging of the human habenula provides sufficient signal-to-noise and contrast to enable identification of the lateral and medial nuclei. In vivo high resolution DWI at 7T is able to distinguish between lateral and medial habenula, and to detect major fiber tracts that connect the habenula with other brain areas.