Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative 
isolated from Pilidiostigma glabrum.

Shou, Q.; Sun, H.; Banbury, L.; Lambley, E. H.; Renshaw, D. E.; Griesinger, C.; Griesser, H. J.; Wohlgemuth, H.

doi:10.1016/j.tetlet.2013.01.107

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Journal Article

Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative isolated from Pilidiostigma glabrum.

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Sun, H.
Department of NMR based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Griesinger, C.
Department of NMR based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Shou, Q., Sun, H., Banbury, L., Lambley, E. H., Renshaw, D. E., Griesinger, C., et al. (2013). Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative isolated from Pilidiostigma glabrum. Tetrahedron Letters, 54(14), 1853-1856. doi:10.1016/j.tetlet.2013.01.107.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-F5C2-4

Abstract

Pilidiostigmin, a novel dimeric acylphloroglucinol derivative, was isolated from the leaves of the Australian plant species Pilidiostigma glabrum (Myrtaceae). Pilidiostigmin exists in the plant in the form of a sodium salt, which is rare in natural products. The elucidation of the structure and relative configuration was achieved by spectroscopic measurements with special emphasis on 1D and 2D NMR techniques. Pilidiostigmin was found to display biological activity; it significantly and dose-dependently inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages at low micromolar concentrations. (C) 2013 Elsevier Ltd. All rights reserved.