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Journal Article

Micro-optical lens array for fluorescence detection in droplet-based microfluidics.

MPS-Authors
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Lim,  Jiseok
Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Konrad,  M.
Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society;

External Ressource
Fulltext (public)

1752386.pdf
(Publisher version), 555KB

Supplementary Material (public)

1752386_Supplement_1.avi
(Supplementary material), 4MB

1752386_Supplement_2.pdf
(Supplementary material), 129KB

1752386_Supplement_3.avi
(Supplementary material), 3MB

1752386_Supplement_4.avi
(Supplementary material), 5MB

Citation

Lim, J., Gruner, P., Konrad, M., & Baret, J. C. (2013). Micro-optical lens array for fluorescence detection in droplet-based microfluidics. Lab on a Chip, 13(8), 1472-1475. doi:10.1039/C3LC41329B.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-7643-6
Abstract
We demonstrate the design and integration of droplet-based microfluidic devices with microoptical element arrays for enhanced detection of fluorescent signals. We show that the integration of microlenses and mirror surfaces in these devices results in an 8-fold increase in the fluorescence signal and in improved spatial resolution. Using an array of microlenses, massively parallel detection of droplets containing fluorescent dyes was achieved, leading to detection throughputs of about 2000 droplets per second and per lens, parallelized over 625 measurement points.