Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

BOLD-perfusion coupling during monocular and binocular stimulation

There are no MPG-Authors in the publication available
External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
Supplementary Material (public)
There is no public supplementary material available

Gauthier, C., & Hoge, R. D. (2008). BOLD-perfusion coupling during monocular and binocular stimulation. International Journal of Biomedical Imaging, 2008: 628718. doi:10.1155/2008/628718.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-77F1-5
Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level-dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism. In the present study, we sought to test this hypoth- esis by measuring BOLD-perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation.