How can measurement, monitoring, modeling and control advance cell culture in 
industrial biotechnology?

Carrondo, Manuel J. T.; Alves, Paula M.; Carinhas, Nuno; Glassey, Jarka; Hesse, Friedemann; Merten, Otto-Wilhelm; Micheletti, Martina; Noll, Thomas; Oliveira, Rui; Reichl, Udo; Staby, Arne; Teixeira, Ana P; Weichert, Henry; Mandenius, Carl-Fredrik

doi:10.1002/biot.201200226

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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

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Reichl, Udo
Otto-von-Guericke-Universität Magdeburg;
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Citation

Carrondo, M. J. T., Alves, P. M., Carinhas, N., Glassey, J., Hesse, F., Merten, O.-W., et al. (2012). How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal, 7(12), 1522-1529. doi:10.1002/biot.201200226.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-8A58-4

Abstract

This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods. Copyright © 1999–2013 John Wiley & Sons, Inc. All Rights Reserved. [accessed January 10th 2013]