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Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system

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Galan,  Kamila
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Elsner,  Martin Peter
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern,  Andreas
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Balawejder, M., Galan, K., Elsner, M. P., Seidel-Morgenstern, A., Piatkowski, W., & Antos, D. (2011). Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system. Chemical Engineering Science, 66(22), 5638-5647. doi:10.1016/j.ces.2011.07.051.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-8DC9-E
Abstract
A systematic procedure for synthesizing the multistage crystallization process was developed for resolution of enantiomeric mixtures involving solid solutions in the crystalline phase. The model compound investigated was citalopram oxalate, which revealed a complete solid solution in the solid phase. The counter-current multi-stage batch crystallization was suggested to isolate the target enantiomer from enantiomerically enriched mixtures. The solid-liquid equilibria in the presence of a solvent and the distribution diagrams were quantified and used in designing the crystallization process and defining adequate processing conditions. Different flowsheet schemes were considered and compared with respect to the process performance. The design procedure was verified by the experimental separation of enantiomeric mixtures of citalopram. Copyright © 2011 Elsevier Ltd All rights reserved. [accessed August 31st 2011]