English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Selective crystallisation of a chiral compound-forming system - Solvent screening, SLE determination and process design

MPS-Authors
/persons/resource/persons86390

Lorenz,  H.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

/persons/resource/persons86477

Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Kaemmerer, H., Jones, M. J., Lorenz, H., & Seidel-Morgenstern, A. (2010). Selective crystallisation of a chiral compound-forming system - Solvent screening, SLE determination and process design. Fluid Phase Equilibria, 296(2), 192-205. doi:10.1016/j.fluid.2010.05.002.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-908D-A
Abstract
A newly developed crystallisation scheme produces single enantiomers from asymmetric mixtures of stereoisomers. The process was modified, adapted and evaluated on bicalutamide, the active pharmaceutical ingredient of the drug Casodex™. A comprehensive solvent/antisolvent screening was carried out based on the COSMO-SAC model and a solvent database of 1432 compounds. Ternary and quaternary phase diagrams of the enantiomers and promising solvent candidates were derived and compared to experimental data. Solid–liquid equilibrium (SLE) model based chiral separation of bicalutamide enantiomers was conducted and the process performance was evaluated in terms of yield and product purity. A concept for internal recycling of process streams enhances the overall yield. Copyright © 2010 Elsevier B.V. All rights reserved. [accessed August 27, 2010]