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Inward Rotating Spiral Waves in Glycolysis

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Straube,  R.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Citation

Straube, R., Vermeer, S., Nicola, E. M., & Mair, T. (2010). Inward Rotating Spiral Waves in Glycolysis. Biophysical Journal, 99(1), L4-L6. doi:10.1016/j.bpj.2010.04.018.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9092-9
Abstract
We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account. Copyright © 2013 Elsevier B.V. All rights reserved. [accessed 2013 July 2nd]