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Coupling chromatography and crystallization for efficient separations of Isomers

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Gedicke,  K.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Sapoundjiev,  D.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Lorenz,  H.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Gedicke, K., Beckmann, W., Brandt, A., Sapoundjiev, D., Lorenz, H., Budde, U., et al. (2005). Coupling chromatography and crystallization for efficient separations of Isomers. Adsorption, 11(1 Supplement), 591-596. doi:10.1007/s10450-005-5990-8.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9CBC-4
Abstract
Within the pharmaceutical industry and in biotechnology there is an increasing need for selective and efficient separation technologies to isolate and purify values-added products. A hybrid process approach combining chromatography and fractional erystallization is studied below. The work presented is concerned with the application and evaluation of this concept in order to isolate a certain pharmaceutical intermediate from a binary mixture. A comparison with performing the same separation exclusively in a single chromatographic process is given also. © Springer, Part of Springer Science+Business Media [accessed 2013 November 27th]