Robustness of Cellular Functions

Stelling, J.; Sauer, U.; Szallasi, Z.; Doyle III, F. J.; Doyle, J.

doi:10.1016/j.cell.2004.09.008

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Robustness of Cellular Functions

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Stelling, J.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Stelling, J., Sauer, U., Szallasi, Z., Doyle III, F. J., & Doyle, J. (2004). Robustness of Cellular Functions. Cell, 118(6), 675-685. doi:10.1016/j.cell.2004.09.008.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-9EA7-D

Abstract

Robustness, the ability to maintain performance in the face of perturbations and uncertainty, is a long-recognized key property of living systems. Owing to intimate links to cellular complexity, however, its molecular and cellular basis has only recently begun to be understood. Theoretical approaches to complex engineered systems can provide guidelines for investigating cellular robustness because biology and engineering employ a common set of basic mechanisms in different combinations. Robustness may be a key to understanding cellular complexity, elucidating design principles, and fostering closer interactions between experimentation and theory. Copyright © 2014 Elsevier B.V. except certain content provided by third parties. [accessed 2014 October 16]