Calculating as many fluxes as possible in underdetermined metabolic networks

Klamt, S.; Schuster, S.

doi:10.1023/A:1020394300385

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Calculating as many fluxes as possible in underdetermined metabolic networks

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Klamt, S.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Klamt, S., & Schuster, S. (2002). Calculating as many fluxes as possible in underdetermined metabolic networks. Molecular Biology Reports, 29(1-2), 243-248. doi:10.1023/A:1020394300385.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-A0C1-F

Abstract

A frequently occurring problem in Metabolic Flux Analysis is that the linear equation systems are underdetermined. A procedure for determining which reaction velocities can be calculated in underdetermined metabolic systems from measured rates and computing these velocities is given. The method is based on the null-space matrix to the stoichiometry matrix corresponding to the reactions with unknown velocities. Moreover, an elementary representation of the null-space is presented. This representation enables one to find those sets of measurable velocities that allow calculation of a certain non-measurable rate. The approach is illustrated by an example from monosaccharide metabolism. © Copyright 2008 Elsevier B.V., All rights reserved. [accessed 2013 June 13th]