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Coupling of simulated moving bed technology and crystallization to separate enantiomers

MPS-Authors
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Kaspereit,  M.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Lorenz,  H.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Kaspereit, M., Lorenz, H., & Seidel-Morgenstern, A. (2002). Coupling of simulated moving bed technology and crystallization to separate enantiomers. In K. Kaneko (Ed.), Fundamentals of Adsorption 7 (pp. 101-108). Shinjuko, Japan: IK International Ltd.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-A114-F
Abstract
The separation of enantiomers is a diffcult task and important in the pharmaceutical industry. Often only with chromatographic methods the required high purity can be reached. In the last years the powerful simulated moving bed (SMB) process was applied successfully to separate a broad spectrum of racemic mixtures. However, chromatographic processes must still be considered as an expensive separation technology. Alternatively enantioseparation is often feasible by crystallization provided a certain enrichment has been achieved. In this work the combination of the two mentioned concepts is discussed.