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Comparing SMB Chromatography with Low Capacity/High Selectivity and High Capacity/Low Selectivity Chiral Stationary Phases

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Kaspereit,  M.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Kaspereit, M., Backovska, V., Skavrada, M., Jandera, P., & Seidel-Morgenstern, A. (2001). Comparing SMB Chromatography with Low Capacity/High Selectivity and High Capacity/Low Selectivity Chiral Stationary Phases. Poster presented at PREP - 14th International Symposium on Preparative/Process Chromatography, Washington, D.C., USA.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-A14C-2
Abstract
Simulated moving bed (SMB) chromatography is increasingly applied in the pharmaceutical industry. Numerous chiral stationary phases (CSPs) exist for enantioseparations. The adsorption behavior of the enantiomers can differ significantly on these CSPs (depending on system, mobile phase composition, adsorption mechanisms, ...). Frequently several CSPs are available to perform the same separation. Objective of this work is to examine the impact of the adsorption equilibrium functions on the productivity in enantioseparations by SMB chromatography for different combinations of CSP/mobile phase.