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Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation

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Lorenz,  H.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Lorenz, H., Sheehan, P., & Seidel-Morgenstern, A. (2001). Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation. Journal of Chromatography A, 908(1-2), 201-214. doi:10.1016/S0021-9673(00)00992-4.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-A1BB-A
Abstract
An optimised coupling of liquid chromatography and fractional crystallisation is suggested for efficient enantioseparation. As a first stage, a chromatographic separation, preferably simulated moving bed chromatography (SMB), is applied to achieve an enantiomeric enrichment sufficient for a subsequent crystallisation. First results of the experimental and modelling work for the model system (+)-/(-)-mandelic acid in an aqueous solution are described. Chromatographic investigations involve the estimation of adsorption isotherms on a suitable chiral stationary phase and the simulation and optimisation of a corresponding SMB-process. From the ternary phase diagram measured for the (+)-/(-)-enantiomer/solvent system, the conditions required to crystallise a pure enantiomer from an asymmetric mixture can be derived. The productivity gains achievable from the combined process compared to the application of chromatography alone are discussed. © 2001 Elsevier Science B.V. [accessed 2013 November 29th]