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Journal Article

Magnetic nanoparticles as mediators of ligand-free activation of EGFR signaling.

MPS-Authors
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Jovin,  T. M.
Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society;

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Arndt-Jovin,  D. J.
Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Bharde, A. A., Palankar, R., Fritsch, C., Klaver, A., Kanger, J. S., Jovin, T. M., et al. (2013). Magnetic nanoparticles as mediators of ligand-free activation of EGFR signaling. PLoS One, 8(7): e68879. doi:10.1371/journal.pone.0068879.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-A6C6-A
Abstract
Magnetic nanoparticles (NPs) are of particular interest in biomedical research, and have been exploited for molecular separation, gene/drug delivery, magnetic resonance imaging, and hyperthermic cancer therapy. In the case of cultured cells, magnetic manipulation of NPs provides the means for studying processes induced by mechanotransduction or by local clustering of targeted macromolecules, e.g. cell surface receptors. The latter are normally activated by binding of their natural ligands mediating key signaling pathways such as those associated with the epidermal growth factor (EGFR). However, it has been reported that EGFR may be dimerized and activated even in the absence of ligands. The present study assessed whether receptor clustering induced by physical means alone suffices for activating EGFR in quiescent cells.